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Ebola virus vaccines - reality or fiction?

Authors :
Mire CE
Geisbert TW
Feldmann H
Marzi A
Source :
Expert review of vaccines [Expert Rev Vaccines] 2016 Nov; Vol. 15 (11), pp. 1421-1430. Date of Electronic Publication: 2016 May 09.
Publication Year :
2016

Abstract

For 40 years ebolaviruses have been responsible for sporadic outbreaks of severe and often fatal hemorrhagic fever in humans and nonhuman primates. In December 2013 an unprecedented Zaire ebolavirus epidemic began in West Africa. Although "patient zero" has finally been reached after 2 years, the virus is again causing disease in the region. Currently there are no licensed vaccines or therapeutic countermeasures against ebolaviruses; however, the epidemic in West Africa has focused attention on the potential vaccine platforms developed over the past 15 years. There has been remarkable progress using a variety of platforms including DNA, subunit, and several viral vector approaches, replicating and non-replicating, which have shown varying degrees of protective efficacy in the "gold-standard" nonhuman primate models for Ebolavirus infections. A number of these vaccine platforms have moved into clinical trials over the past year with the hope of finding an efficacious vaccine to prevent future outbreaks/epidemics of Ebola hemorrhagic fever on the scale of the West African epidemic.<br />Competing Interests: Declaration of Interests The authors have no other relevant affiliations or financial involvement with any organization or entity with financial interest or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Details

Language :
English
ISSN :
1744-8395
Volume :
15
Issue :
11
Database :
MEDLINE
Journal :
Expert review of vaccines
Publication Type :
Academic Journal
Accession number :
27078187
Full Text :
https://doi.org/10.1080/14760584.2016.1178068