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Solid Variant of Adenoid Cystic Carcinoma: Difficulties in Diagnostic Recognition.
- Source :
-
International journal of surgical pathology [Int J Surg Pathol] 2016 Aug; Vol. 24 (5), pp. 419-24. Date of Electronic Publication: 2016 Apr 10. - Publication Year :
- 2016
-
Abstract
- Adenoid cystic carcinoma (ACC) is a malignant neoplasm that mainly affects the salivary glands but has been described in many other anatomical sites. It is composed of basaloid cells with myoepithelial/basal cell differentiation and ductal epithelial cells that proliferate in a fibrous stroma, with variable amounts of myxohyaline material. Three patterns (cribriform, tubular, and solid) occur, and the solid variant is characterized by a predominant compact sheet-like and nested pattern of rounded basaloid cells lacking obvious cribriform or tubular architecture. The solid variant has significant morphological and immunohistochemical overlap with a large range of neoplasms of different lineages, including other carcinomas and sarcomas. We describe a case of solid variant ACC of the paranasal sinuses, which showed an almost entirely solid pattern of growth (in >95% of cells) and which on initial biopsy showed no features of classical ACC. This highlights the potential for diagnostic misinterpretation with a variety of other neoplasms, which is particularly important because of the significant difference in treatment for ACC and tumors in its differential diagnosis.<br /> (© The Author(s) 2016.)
Details
- Language :
- English
- ISSN :
- 1940-2465
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of surgical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 27069025
- Full Text :
- https://doi.org/10.1177/1066896916642011