Comparative In Vitro Activities of Oritavancin, Dalbavancin, and Vancomycin against Methicillin-Resistant Staphylococcus aureus Isolates in a Nondividing State.

Authors :: Belley A
Lalonde Seguin D
Arhin F
Moeck G
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Jun 20; Vol. 60 (7), pp. 4342-5. Date of Electronic Publication: 2016 Jun 20 (Print Publication: 2016).
Publication Year :: 2016
Abstract: Antibacterial agents that kill nondividing bacteria may be of utility in treating persistent infections. Oritavancin and dalbavancin are bactericidal lipoglycopeptides that are approved for acute bacterial skin and skin structure infections in adults caused by susceptible Gram-positive pathogens. Using time-kill methodology, we demonstrate that oritavancin exerts bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) isolates that are maintained in a nondividing state in vitro, whereas dalbavancin and the glycopeptide vancomycin do not.<br /> (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)

Subjects :: Lipoglycopeptides
Microbial Sensitivity Tests
Teicoplanin pharmacology
Anti-Bacterial Agents pharmacology
Glycopeptides pharmacology
Methicillin-Resistant Staphylococcus aureus drug effects
Teicoplanin analogs & derivatives
Vancomycin pharmacology

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