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An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull.
- Source :
-
Developmental biology [Dev Biol] 2016 Jul 15; Vol. 415 (2), pp. 261-277. Date of Electronic Publication: 2016 Apr 07. - Publication Year :
- 2016
-
Abstract
- The neurocranium generates most of the craniofacial skeleton and consists of prechordal and postchordal regions. Although development of the prechordal is well studied, little is known of the postchordal region. Here we characterize a signaling hierarchy necessary for postchordal neurocranial development involving Fibroblast growth factor (Fgf) signaling for early specification of mesodermally-derived progenitor cells. The expression of hyaluron synthetase 2 (has2) in the cephalic mesoderm requires Fgf signaling and Has2 function, in turn, is required for postchordal neurocranial development. While Hedgehog (Hh)-deficient embryos also lack a postchordal neurocranium, this appears primarily due to a later defect in chondrocyte differentiation. Inhibitor studies demonstrate that postchordal neurocranial development requires early Fgf and later Hh signaling. Collectively, our results provide a mechanistic understanding of early postchordal neurocranial development and demonstrate a hierarchy of signaling between Fgf and Hh in the development of this structure.<br /> (Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Cell Differentiation
Fibroblast Growth Factor 3 deficiency
Fibroblast Growth Factor 3 genetics
Fibroblast Growth Factors deficiency
Fibroblast Growth Factors genetics
Gene Expression Regulation, Developmental
Glucuronosyltransferase genetics
Hedgehog Proteins genetics
Hyaluronan Synthases
Mesoderm embryology
Mesoderm metabolism
Skull metabolism
Zebrafish genetics
Zebrafish Proteins deficiency
Zebrafish Proteins genetics
Fibroblast Growth Factor 3 physiology
Fibroblast Growth Factors physiology
Glucuronosyltransferase physiology
Hedgehog Proteins physiology
Signal Transduction
Skull embryology
Zebrafish embryology
Zebrafish Proteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-564X
- Volume :
- 415
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 27060628
- Full Text :
- https://doi.org/10.1016/j.ydbio.2016.04.005