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COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions.
- Source :
-
Schizophrenia research [Schizophr Res] 2016 Jul; Vol. 174 (1-3), pp. 24-28. Date of Electronic Publication: 2016 Apr 01. - Publication Year :
- 2016
-
Abstract
- Background: Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis.<br />Methods: Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial.<br />Results: Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele.<br />Conclusions: Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Cannabis
Female
Gene-Environment Interaction
Genotype
Genotyping Techniques
Humans
Male
Polymorphism, Genetic
Psychiatric Status Rating Scales
Psychotic Disorders complications
Severity of Illness Index
Young Adult
Catechol O-Methyltransferase genetics
Genetic Predisposition to Disease
Marijuana Smoking genetics
Marijuana Smoking psychology
Psychotic Disorders genetics
Psychotic Disorders psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2509
- Volume :
- 174
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 27052366
- Full Text :
- https://doi.org/10.1016/j.schres.2016.03.015