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Long-Term Effect of Anti-VEGF Agents on Intraocular Pressure in Age-Related Macular Degeneration.
- Source :
-
Ophthalmic research [Ophthalmic Res] 2016; Vol. 56 (1), pp. 30-4. Date of Electronic Publication: 2016 Apr 06. - Publication Year :
- 2016
-
Abstract
- Purpose: To analyze the effect of anti-vascular endothelial growth factor (VEGF) agents on intraocular pressure (IOP) in patients with neovascular age-related macular degeneration (AMD). Materials andMethods: This is a retrospective study that included 72 patients treated unilaterally with anti-VEGF agents according to a pro re nata regimen. Fellow noninjected eyes (n = 72) were used as controls. IOP variation and the development of sustained ocular hypertension (OHT) were assessed both in the injected and in the fellow eyes.<br />Results: While the final IOP was not significantly different between the 2 groups, sustained OHT developed in 4.2% of the injected eyes and 1.4% of the controls. In the study group, no significant IOP variation was noted during follow-up in patients receiving ≤20 injections, but there was a significant increase in IOP with time in more frequently treated patients (p = 0.041). Comparison of both subgroups demonstrated that patients receiving >20 injections suffered significantly greater IOP variation (p = 0.034) during follow-up, and that these patients tended to require IOP-lowering treatment more frequently (p = 0.090).<br />Conclusion: Multiple anti-VEGF injections lead to an increase in IOP, although this variation is not sufficient to cause development of OHT in the majority of patients.<br /> (© 2016 S. Karger AG, Basel.)
- Subjects :
- Aged
Aged, 80 and over
Angiogenesis Inhibitors administration & dosage
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Intravitreal Injections
Macular Degeneration diagnosis
Macular Degeneration physiopathology
Male
Middle Aged
Retrospective Studies
Time Factors
Tomography, Optical Coherence
Treatment Outcome
Visual Acuity
Bevacizumab administration & dosage
Intraocular Pressure drug effects
Macular Degeneration drug therapy
Ranibizumab administration & dosage
Receptors, Vascular Endothelial Growth Factor administration & dosage
Recombinant Fusion Proteins administration & dosage
Vascular Endothelial Growth Factor A antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0259
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Ophthalmic research
- Publication Type :
- Academic Journal
- Accession number :
- 27046391
- Full Text :
- https://doi.org/10.1159/000444395