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Effects of Piper sarmentosum extract on the growth performance, antioxidant capability and immune response in weaned piglets.
- Source :
-
Journal of animal physiology and animal nutrition [J Anim Physiol Anim Nutr (Berl)] 2017 Feb; Vol. 101 (1), pp. 105-112. Date of Electronic Publication: 2016 Apr 04. - Publication Year :
- 2017
-
Abstract
- The biological properties of Piper sarmentosum render it a potential substitute for antibiotics in livestock feed. This study evaluated the effects of P. sarmentosum extract (PSE) on the growth performance, antioxidant capability and immune response of weaned piglets. Eighty 21-d-old weaned piglets were selected and randomly allocated to one of four dietary treatments with five replicates of four pigs each. The dietary treatments consisted of a basal diet supplemented with 0 (T0), 50 (T50), 100 (T100) or 200 (T200) mg/kg PSE. The feeding trial lasted 4 weeks. The results revealed that the T50 group had the highest average daily gain (ADG) and average daily feed intake (ADFI) throughout the feeding trial (p < 0.05). Additionally, the T50 group had higher (p < 0.05) serum glutathione peroxidase activity (GSH-Px) and lower (p < 0.05) serum malondialdehyde (MDA) levels than the T0 group at 4 weeks post-weaning (p < 0.05). Serum levels of interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) decreased, while serum levels of interleukin-4 (IL-4), interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) increased by PSE supplementation at 4 weeks post-weaning (p < 0.05). PSE supplementation upregulated the mRNA expression of IL-4, IL-10 and TGF-β and downregulated the mRNA expression of TNF-α, IL-1β and interleukin-6 (IL-6) in the ileal mucosal layer of piglets (p < 0.05). In summary, our study findings revealed that PSE supplementation improved the antioxidant capability, and reduced inflammation, which may be beneficial to weaned piglet health.<br /> (Journal of Animal Physiology and Animal Nutrition © 2016 Blackwell Verlag GmbH.)
- Subjects :
- Animal Feed analysis
Animal Nutritional Physiological Phenomena
Animals
Cytokines
Diet veterinary
Gene Expression Regulation, Developmental drug effects
Glutathione Peroxidase genetics
Glutathione Peroxidase metabolism
Malondialdehyde metabolism
Plant Extracts chemistry
RNA, Messenger genetics
RNA, Messenger metabolism
Superoxide Dismutase genetics
Superoxide Dismutase metabolism
Swine immunology
Weight Gain
Antioxidants metabolism
Piper chemistry
Plant Extracts pharmacology
Swine physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0396
- Volume :
- 101
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of animal physiology and animal nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 27045971
- Full Text :
- https://doi.org/10.1111/jpn.12517