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Stereoselective Total Synthesis of Bioactive Marine Natural Product Biselyngbyolide B.

Authors :
Das S
Paul D
Goswami RK
Source :
Organic letters [Org Lett] 2016 Apr 15; Vol. 18 (8), pp. 1908-11. Date of Electronic Publication: 2016 Apr 04.
Publication Year :
2016

Abstract

A convergent strategy for the stereoselective total synthesis of biologically active marine natural product biselyngbyolide B has been developed. Key strategies of this synthesis include Jamison protocol of trans-hydroalumination/allylation for installation of C18-C23 olefin moiety and intramolecular Heck coupling for macrocyclization.

Subjects

Subjects :
Alkenes chemistry
Biological Products chemistry
Cyclization
Diterpenes chemistry
Macrolides chemistry
Marine Biology
Molecular Structure
Stereoisomerism
Biological Products chemical synthesis
Diterpenes metabolism
Diterpenes pharmacology
Macrolides chemical synthesis

Details

Language :
English
ISSN :
1523-7052
Volume :
18
Issue :
8
Database :
MEDLINE
Journal :
Organic letters
Publication Type :
Academic Journal
Accession number :
27043308
Full Text :
https://doi.org/10.1021/acs.orglett.6b00713
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