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Antibody therapy alone and in combination with targeted drugs in chronic lymphocytic leukemia.
- Source :
-
Seminars in oncology [Semin Oncol] 2016 Apr; Vol. 43 (2), pp. 280-90. Date of Electronic Publication: 2016 Feb 08. - Publication Year :
- 2016
-
Abstract
- The development of non-chemotherapeutic agents, including monoclonal antibodies (mAbs) and other targeted drugs, makes chemotherapy-free treatment an attractive option for chronic lymphocytic leukemia (CLL). The classical mAb, rituximab, has been authorized for use in both first-line and second-line therapy for CLL. New mAbs directed against CD20, ofatumumab, and obinutuzumab (GA-101) have also been approved for the treatment of this disease. Recently, several new mAbs with potential benefits over the approved anti-CD20 antibodies have been developed for use in CLL. Anti-CD37, anti-CD19, and anti-CD40 mAbs are in early clinical trials and show promise in treating CLL. In addition, the combination of mAbs with B-cell receptor signaling pathway inhibitors and immunomodulatory drugs makes the chemotherapy-free option a reality today. Combinations of antibodies with targeted drugs like ibrutinib, idelalisib, or lenalidomide are expected to replace chemotherapy-based combinations for treating CLL in the near future. However, phase III trials should confirm the benefit of these new treatment strategies and establish their exact place in the therapeutic armamentarium for CLL.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Antibodies, Monoclonal administration & dosage
Antibodies, Monoclonal adverse effects
Antineoplastic Agents administration & dosage
Antineoplastic Agents adverse effects
Clinical Trials as Topic
Humans
Leukemia, Lymphocytic, Chronic, B-Cell mortality
Leukemia, Lymphocytic, Chronic, B-Cell pathology
Molecular Targeted Therapy
Protein Kinase Inhibitors administration & dosage
Treatment Outcome
Antibodies, Monoclonal therapeutic use
Antineoplastic Agents therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8708
- Volume :
- 43
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Seminars in oncology
- Publication Type :
- Academic Journal
- Accession number :
- 27040707
- Full Text :
- https://doi.org/10.1053/j.seminoncol.2016.02.010