Back to Search
Start Over
Unexpected Photo-instability of 2,6-Sulfonamide-Substituted BODIPYs and Its Application to Caged GABA.
- Source :
-
Chembiochem : a European journal of chemical biology [Chembiochem] 2016 Jul 01; Vol. 17 (13), pp. 1233-40. Date of Electronic Publication: 2016 May 23. - Publication Year :
- 2016
-
Abstract
- Investigation of the unexpected photo-instability of 2,6-sulfonamide-substituted derivatives of the boron dipyrromethene (BODIPY) fluorophore led to the discovery of a photoreaction accompanied by multiple bond scissions. We characterized the photoproducts and utilized the photoreaction to design a caged γ-aminobutyric acid (GABA) derivative that can release GABA upon irradiation in the visible range (>450 nm). This allowed us to stimulate neural cells in mouse brain slices.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Acetaldehyde analysis
Animals
Baclofen pharmacology
Basolateral Nuclear Complex drug effects
Basolateral Nuclear Complex physiology
Boron Compounds chemical synthesis
Boron Compounds chemistry
Formaldehyde analysis
GABA Antagonists pharmacology
HeLa Cells
Humans
Light
Methylamines analysis
Mice
Picrotoxin pharmacology
Sulfonamides chemical synthesis
Sulfonamides chemistry
Boron Compounds radiation effects
Sulfonamides radiation effects
gamma-Aminobutyric Acid analogs & derivatives
gamma-Aminobutyric Acid pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1439-7633
- Volume :
- 17
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Chembiochem : a European journal of chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 27038199
- Full Text :
- https://doi.org/10.1002/cbic.201600097