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Low Vital Capacity Was Associated with Incident Diabetes in a Japanese Health Screening Population in Whom Obesity Was Not Prevalent.
- Source :
-
Canadian journal of diabetes [Can J Diabetes] 2016 Apr; Vol. 40 (2), pp. 143-8. - Publication Year :
- 2016
-
Abstract
- Objectives: There have been few studies regarding the relationship between respiratory function and incident diabetes in East Asian populations in whom obesity is not prevalent.<br />Methods: This is a 6-year follow-up study in a Japanese health-screening population that included 1874 men and 1093 women. Using Cox regression models, hazard ratios (HRs) of incident diabetes for percent vital capacity (%VC) and forced expiratory volume in 1 second divided by forced vital capacity (FEV1/FVC) were calculated. Diabetes was defined as simultaneous fasting plasma glucose (FPG) ≥7.0 mmol/L and glycated hemoglobin (A1C) ≥6.5% or use of antidiabetic medications.<br />Results: During the 6-year follow-up period (mean of 4.8 years), 71 men (3.8%) and 18 women (1.7%) developed diabetes. The HRs (95% confidence intervals [CIs]) of incident diabetes for each 1 SD increase in %VC and the lowest tertile of %VC compared with the highest tertile were 0.81 (0.66 to 1.00) (p=0.045) and 1.78 (1.01 to 3.16) (p=0.048), respectively, adjusted for sex, age, body mass index, antihypertensive drug use and A1C levels. After further adjustment for log high-sensitivity C-reactive protein, the HRs (95% CI) of incident diabetes for each 1 SD increase in %VC and the lowest tertile of %VC were 0.82 (0.67 to 1.01) (p=0.063) and 1.69 (0.95 to 3.01) (p=0.073), respectively. The association between FEV1/FVC and incident diabetes was not significant.<br />Conclusions: %VC, but not FEV1/FVC, was significantly associated with incident diabetes in a Japanese health-screening population in whom obesity was not prevalent.<br /> (Copyright © 2016 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Blood Glucose analysis
Cohort Studies
Diabetes Mellitus metabolism
Diabetes Mellitus physiopathology
Female
Follow-Up Studies
Forced Expiratory Volume
Glycated Hemoglobin analysis
Humans
Incidence
Japan epidemiology
Male
Middle Aged
Prognosis
Diabetes Mellitus epidemiology
Mass Screening
Obesity physiopathology
Respiratory Function Tests methods
Vital Capacity physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2352-3840
- Volume :
- 40
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Canadian journal of diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 27038138
- Full Text :
- https://doi.org/10.1016/j.jcjd.2015.09.003