Histone Modifications and Cancer.

Authors :: Audia JE
Campbell RM
Source :: Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2016 Apr 01; Vol. 8 (4), pp. a019521. Date of Electronic Publication: 2016 Apr 01.
Publication Year :: 2016
Abstract: Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In this article, we review many of the key and newly identified histone modifications known to be deregulated in cancer and how this impacts function. The latter part of the article addresses the challenges and current status of the epigenetic drug development process as it applies to cancer therapeutics.<br /> (Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.)