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Impact of thyroid autoimmunity on cumulative delivery rates in in vitro fertilization/intracytoplasmic sperm injection patients.
- Source :
-
Fertility and sterility [Fertil Steril] 2016 Jul; Vol. 106 (1), pp. 144-150. Date of Electronic Publication: 2016 Mar 29. - Publication Year :
- 2016
-
Abstract
- Objective: To predict the impact of thyroid autoimmunity (TAI) on the probability of delivery after a defined number of treatment cycles, using analysis of cumulative delivery rates in patients with and without TAI.<br />Design: Retrospective cohort study performed at the Center for Reproductive Medicine and Department of Endocrinology, University Hospital of Brussels, approved by the institutional review board of the hospital.<br />Setting: University hospital.<br />Patient(s): All patients who started their first IVF/intracytoplasmic sperm injection cycle at our fertility center between January 1, 2010 and December 31, 2011 were included.<br />Main Outcome Measure(s): Live birth delivery after 25 weeks' gestation was taken as the primary endpoint of our study Cumulative delivery rates were calculated for both groups until six treatment cycles.<br />Intervention(s): All patients (in both groups) received the usual IVF treatment protocols (i.e., antagonist or agonist protocol).<br />Result(s): In total 2,406 women who consulted our center were included. We included 333 patients with TAI and 2019 patients without TAI. In the TAI group the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 65%. In our control the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 76%.<br />Conclusion(s): Our study did not confirm an influence of TAI status in patients undergoing fertility treatment on cumulative delivery rates after six IVF/intracytoplasmic sperm injection cycles.<br /> (Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Autoantibodies blood
Autoantigens immunology
Autoimmune Diseases blood
Autoimmune Diseases diagnosis
Autoimmune Diseases immunology
Belgium
Biomarkers blood
Embryo Implantation
Embryo Transfer
Female
Fertility
Hospitals, University
Humans
Infertility complications
Infertility diagnosis
Infertility physiopathology
Iodide Peroxidase immunology
Iron-Binding Proteins immunology
Live Birth
Male
Middle Aged
Pregnancy
Pregnancy Rate
Retrospective Studies
Risk Factors
Thyroid Diseases blood
Thyroid Diseases diagnosis
Thyroid Diseases immunology
Thyroid Hormones blood
Treatment Outcome
Young Adult
Autoimmune Diseases complications
Autoimmunity
Fertilization in Vitro adverse effects
Infertility therapy
Sperm Injections, Intracytoplasmic adverse effects
Thyroid Diseases complications
Thyroid Gland immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 106
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 27036234
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2016.03.011