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[The effect and safety of tirofiban on acute ST segment elevation myocardial infarction patients receiving no early reperfusion therapy].
- Source :
-
Zhonghua nei ke za zhi [Zhonghua Nei Ke Za Zhi] 2016 Apr 01; Vol. 55 (4), pp. 273-7. - Publication Year :
- 2016
-
Abstract
- Objective: To study the efficacy and safety of tirofiban on acute ST segment elevation myocardial infarction (STEMI) in patients who do not receive early reperfusion therapy.<br />Methods: A total of 153 STEMI patients without early reperfusion therapy were randomly distributed into tirofiban group (therapeutic group, n=78) and non-tirofiban group (control group, n=75). Coronary angiography was performed on the 5(th) and 10(th) day after treatment, and percutaneous coronary intervention (PCI) was conducted when necessary. The differences of initial patency of the infarct related artery (IRA), bleeding complication and clinic events within 30 days between these two groups were compared.<br />Results: Tirofiban did not increase the percentage of patients with initial patency of IRA (60.3% vs 64.0%, P=0.63). The percentage of patients with thrombolysis in myocardial infarction (TIMI) 3 after PCI was 100.0% in tirofiban group and 97.1% in the control group (P=0.09). However, application of tirofiban significantly decreased poor myocardial perfusion rate after PCI (1.4% vs 8.8%, P=0.04). No significant differences were observed in major adverse cardiovascular events (MACE) (3.8% vs 2.7%, P=0.68) between therapeutic and control group. The same is true for mild (5/78 vs 4/75 cases, P=0.78) and severe hemorrhage (2/78 vs 1/75 cases, P=0.58), and severe thrombocytopenia (2/78 vs 0/75 cases, P=0.10) between these two groups within 30 days.<br />Conclusions: Tirofiban did not increase initial patency in STEMI patients without early reperfusion therapy. However, it can improve myocardial perfusion after PCI.
- Subjects :
- Aged
Coronary Angiography
Female
Humans
Male
Middle Aged
Myocardial Infarction drug therapy
Myocardial Infarction physiopathology
Percutaneous Coronary Intervention
Platelet Aggregation Inhibitors adverse effects
ST Elevation Myocardial Infarction
Safety
Secondary Prevention
Tirofiban
Treatment Outcome
Tyrosine adverse effects
Tyrosine therapeutic use
Angioplasty, Balloon, Coronary
Myocardial Infarction therapy
Platelet Aggregation Inhibitors therapeutic use
Tyrosine analogs & derivatives
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0578-1426
- Volume :
- 55
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhonghua nei ke za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 27030614
- Full Text :
- https://doi.org/10.3760/cma.j.issn.0578-1426.2016.04.005