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The importance of understanding individual differences in Down syndrome.
- Source :
-
F1000Research [F1000Res] 2016 Mar 23; Vol. 5. Date of Electronic Publication: 2016 Mar 23 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide range of individual differences at every level of description. We argue that, in the context of significant increases in DS life expectancy, a focus on individual differences in trisomy 21 at all levels-genetic, cellular, neural, cognitive, behavioral, and environmental-constitutes one of the best approaches for understanding genotype/phenotype relations in DS and for exploring risk and protective factors for Alzheimer's disease in this high-risk population.
Details
- Language :
- English
- ISSN :
- 2046-1402
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- F1000Research
- Publication Type :
- Academic Journal
- Accession number :
- 27019699
- Full Text :
- https://doi.org/10.12688/f1000research.7506.1