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Leptin, IL-6 and TNF-α levels in umbilical cord blood of healthy term newborns in relation to mode of delivery.

Authors :
Treviño-Garza C
Villarreal-Martínez L
Estrada-Zúñiga CM
Leal-Treviño M
Rodríguez-Balderrama I
Nieto-Sanjuanero A
Cárdenas-Del Castillo B
Montes-Tapia FF
de la O-Cavazos M
Source :
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology [J Obstet Gynaecol] 2016 Aug; Vol. 36 (6), pp. 719-721. Date of Electronic Publication: 2016 Mar 25.
Publication Year :
2016

Abstract

In the development of the foetal immune system, cytokines play an important role in its function. Therefore, we sought to determine whether the mode of delivery affects the expression of leptin, IL-6 and TNF-α in umbilical cord blood in healthy term newborns. We collected 125 samples of umbilical cord blood to analyse leptin, IL-6 y TNF-α levels with multiplex immunoassay (MIA). The samples were classified according to mode of delivery: vaginal delivery (VD) and caesarean section (CS). Leptin and IL-6 had higher concentrations in umbilical cord blood in VD than in CS: 42.55 ng/ml (11.92-104.28) versus 35.20 ng/ml (3.26-9326.76), p  =  0.039; 9.32 pg/ml (1.13-2020.31) versus 3.81 pg/ml (0.52-834.69) p < 0.001, respectively. Also, a weak correlation between TNF-α and IL-6 was found (r = 0.238, p = 0.007). The most important finding in our study was the differential concentrations of leptin and IL-6 according to mode of delivery.

Details

Language :
English
ISSN :
1364-6893
Volume :
36
Issue :
6
Database :
MEDLINE
Journal :
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Publication Type :
Academic Journal
Accession number :
27012976
Full Text :
https://doi.org/10.3109/01443615.2016.1148128