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First Morning Voided Urinary Gonadotropin Measurements as an Alternative to the GnRH Test.
- Source :
-
Hormone research in paediatrics [Horm Res Paediatr] 2016; Vol. 85 (5), pp. 301-8. Date of Electronic Publication: 2016 Mar 25. - Publication Year :
- 2016
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Abstract
- Aims: We studied whether first morning voided (FMV) urinary gonadotropin measurements could be used as a noninvasive alternative to the GnRH test in the assessment of the hypothalamic-pituitary-gonadal function in children.<br />Methods: In a single-center study, we compared FMV urinary gonadotropin concentrations with basal and GnRH-stimulated serum gonadotropin levels in 274 children and adolescents (78 girls, 196 boys) aged 5-17 years referred for growth and pubertal disorders. The concordance between FMV urinary gonadotropin concentrations and GnRH test results was assessed.<br />Results: FMV urinary LH (U-LH), urinary FSH (U-FSH) and their ratios correlated well with the corresponding basal and GnRH-stimulated serum parameters (r ≥ 0.66, p < 0.001). Receiver operating characteristic curve analyses using urinary and serum LH and FSH concentrations showed that FMV U-LH and U-LH/U-FSH performed equally well as the GnRH test in the differentiation of early puberty (Tanner stage 2) from prepuberty (Tanner stage 1) (area under the curve 0.768-0.890 vs. 0.712-0.858). FMV U-LH and U-LH/U-FSH performed equally well as basal serum LH in predicting a pubertal GnRH test result (area under the curve 0.90-0.93).<br />Conclusion: FMV U-LH determination can be used for the evaluation of pubertal development and its disorders, reducing the need for invasive GnRH stimulation tests.<br /> (© 2016 S. Karger AG, Basel.)
- Subjects :
- Adolescent
Child
Female
Humans
Male
Gonadotropins urine
Puberty urine
Subjects
Details
- Language :
- English
- ISSN :
- 1663-2826
- Volume :
- 85
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Hormone research in paediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 27011314
- Full Text :
- https://doi.org/10.1159/000440955