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Matrix ageing and vascular impacts: focus on elastin fragmentation.
- Source :
-
Cardiovascular research [Cardiovasc Res] 2016 Jun 01; Vol. 110 (3), pp. 298-308. Date of Electronic Publication: 2016 Mar 22. - Publication Year :
- 2016
-
Abstract
- Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a major problem of public health. Over the years, life expectancy has considerably increased throughout the world, and the prevalence of CVD is inevitably rising with the growing ageing of the population. The normal process of ageing is associated with progressive deterioration in structure and function of the vasculature, commonly called vascular ageing. At the vascular level, extracellular matrix (ECM) ageing leads to molecular alterations in long half-life proteins, such as elastin and collagen, and have critical effects on vascular diseases. This review highlights ECM alterations occurring during vascular ageing with a specific focus on elastin fragmentation and also the contribution of elastin-derived peptides (EDP) in age-related vascular complications. Moreover, current and new pharmacological strategies aiming at minimizing elastin degradation, EDP generation, and associated biological effects are discussed. These strategies may be of major relevance for preventing and/or delaying vascular ageing and its complications.<br /> (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.)
- Subjects :
- Aging pathology
Animals
Arteries drug effects
Arteries pathology
Cardiovascular Agents therapeutic use
Extracellular Matrix drug effects
Extracellular Matrix pathology
Glycoside Hydrolase Inhibitors therapeutic use
Humans
Molecular Targeted Therapy
Neuraminidase antagonists & inhibitors
Neuraminidase metabolism
Pancreatic Elastase antagonists & inhibitors
Pancreatic Elastase metabolism
Proteolysis
Serine Proteinase Inhibitors therapeutic use
Signal Transduction drug effects
Vascular Diseases drug therapy
Vascular Diseases pathology
Aging metabolism
Arteries metabolism
Elastin metabolism
Extracellular Matrix metabolism
Peptide Fragments metabolism
Vascular Diseases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1755-3245
- Volume :
- 110
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cardiovascular research
- Publication Type :
- Academic Journal
- Accession number :
- 27009176
- Full Text :
- https://doi.org/10.1093/cvr/cvw061