The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells.

Authors :: Bimonte S
Barbieri A
Leongito M
Palma G
Del Vecchio V
Falco M
Palaia R
Albino V
Piccirillo M
Amore A
Petrillo A
Granata V
Izzo F
Source :: Stem cells international [Stem Cells Int] 2016; Vol. 2016, pp. 8352684. Date of Electronic Publication: 2016 Feb 24.
Publication Year :: 2016
Abstract: Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.