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HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response.
- Source :
-
Mediators of inflammation [Mediators Inflamm] 2016; Vol. 2016, pp. 1478340. Date of Electronic Publication: 2016 Mar 02. - Publication Year :
- 2016
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Abstract
- Introduction: Our objective is to understand how HIV infection increases the risk of progression from latent tuberculosis (TB) to active disease. We understand now that immunity is a balance of competing immune responses by multiple cell types. Since T-lymphocyte production of interferon-gamma (IFN-γ) in response to Mycobacterium tuberculosis (Mtb) antigens fails to differentiate disease from latent infection, we applied a comprehensive profiling methodology to define immune biomarkers that reliably predict a patient's TB risk.<br />Methods: We established a cohort of HIV-infected adults with TB disease from Swaziland. Multiparametric flow cytometry was used to quantify the mycobacterial-specific anti-inflammatory (IL-4 and IL-10) and proinflammatory (IFN-γ) immune response.<br />Results: From 12 HIV-infected Swaziland patients with TB disease, the CD4(+), CD8(+), Double Negative, and CD56(+)CD3(-) lymphocytes increase their IL-4 : IFN-γ ratio as HIV disease worsens (Spearman r of -0.59; -0.59; -0.60; and -0.59, resp.; p < 0.05). Similarly, HIV severity is associated with an increased IL-10 : IFN-γ ratio (Spearman r of -0.76; p = 0.01).<br />Conclusion: As HIV disease progresses, both the adaptive and innate branches skew away from an inflammatory and towards anti-inflammatory phenotype.
- Subjects :
- Adaptive Immunity genetics
Adolescent
Adult
Antigens, Bacterial immunology
CD3 Complex metabolism
CD4-Positive T-Lymphocytes metabolism
CD56 Antigen metabolism
CD8-Positive T-Lymphocytes metabolism
Female
Humans
Immunity, Innate genetics
Interferon-gamma metabolism
Interleukin-10 metabolism
Interleukin-4 metabolism
Male
Mycobacterium tuberculosis pathogenicity
Young Adult
Adaptive Immunity physiology
HIV Infections complications
HIV Infections immunology
Immunity, Innate physiology
Mycobacterium tuberculosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1466-1861
- Volume :
- 2016
- Database :
- MEDLINE
- Journal :
- Mediators of inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 27006526
- Full Text :
- https://doi.org/10.1155/2016/1478340