Back to Search
Start Over
Therapeutic expansion of CD4+FoxP3+ regulatory T cells limits allergic airway inflammation during pulmonary fungal infection.
- Source :
-
Pathogens and disease [Pathog Dis] 2016 Jun; Vol. 74 (4), pp. ftw020. Date of Electronic Publication: 2016 Mar 21. - Publication Year :
- 2016
-
Abstract
- Allergic asthma can be frequently caused and exacerbated by sensitization to ubiquitous fungal allergens associated with pulmonary mucus production, airway hyperresponsiveness and bronchial constriction, resulting in a complex disease that is often difficult to treat. Fungal infections are frequently complicated by the development of a type 2 immune response that prevents successful elimination of the fungal pathogen. Furthermore, production of type 2 cytokines triggers allergic airway inflammation. Following intranasal infection of BALB/c mice with the fungusCryptococcus neoformans, we recently described a more pronounced type 2 immune response in the absence of regulatory T (Treg) cells. To determine whether Treg cell expansion is able to suppress type 2-related fungal allergic inflammation, we increased Treg cell numbers during pulmonaryC. neoformansinfection by administration of an interleukin (IL)-2/anti-IL-2 complex. Expansion of Treg cells resulted in reduced immunoglobulin E production and decreased allergic airway inflammation including reduced production of pulmonary mucus and type 2 cytokines as well as production of immunosuppressive cytokines such as IL-10 and transforming growth factor-β1. From our data we conclude that Treg cells and/or their suppressive mediators represent potential targets for therapeutic intervention during allergic fungal airway disease.<br /> (© FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Animals
Colony Count, Microbial
Cryptococcus neoformans immunology
Cytokines metabolism
Disease Models, Animal
Female
Immunoglobulin E blood
Immunoglobulin E immunology
Immunomodulation
Inflammation Mediators metabolism
Lung Diseases, Fungal microbiology
Lung Diseases, Fungal pathology
Lymphocyte Activation immunology
Lymphocyte Count
Mice
T-Lymphocyte Subsets metabolism
T-Lymphocytes, Regulatory metabolism
Th2 Cells immunology
Th2 Cells metabolism
Lung Diseases, Fungal complications
Lung Diseases, Fungal immunology
Respiratory Hypersensitivity complications
Respiratory Hypersensitivity immunology
T-Lymphocyte Subsets immunology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2049-632X
- Volume :
- 74
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pathogens and disease
- Publication Type :
- Academic Journal
- Accession number :
- 27001975
- Full Text :
- https://doi.org/10.1093/femspd/ftw020