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Light-emitting diode therapy reduces persistent inflammatory pain: Role of interleukin 10 and antioxidant enzymes.
- Source :
-
Neuroscience [Neuroscience] 2016 Jun 02; Vol. 324, pp. 485-95. Date of Electronic Publication: 2016 Mar 18. - Publication Year :
- 2016
-
Abstract
- Background: During the last decades, the use of light-emitting diode therapy (LEDT) has increased significantly for the treatment of wound healing, analgesia and inflammatory processes. Nevertheless, scientific data on the mechanisms responsible for the therapeutic effect of LEDT are still insufficient. Thus, this study investigated the analgesic, anti-inflammatory and anti-oxidative effect of LEDT in the model of chronic inflammatory hyperalgesia.<br />Experimental Procedures: Mice injected with Complete Freund's Adjuvant (CFA) underwent behavioral, i.e. mechanical and hot hyperalgesia; determination of cytokine levels (tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), IL-10), oxidative stress markers (protein carbonyls and thiobarbituric acid reactive species (TBARS)) and antioxidant enzymes (catalase (CAT) and superoxide dismutase (SOD)). Additionally, mice were pretreated with either naloxone or fucoidin and mechanical hyperalgesia was assessed.<br />Results: LEDT inhibited mechanical and thermal hyperalgesia induced by CFA injection. LEDT did not reduce paw edema, neither influenced the levels of TNF-α and IL1-β; although it increased the levels of IL-10. LEDT significantly prevented TBARS increase in both acute and chronic phases post-CFA injection; whereas protein carbonyl levels were reduced only in the acute phase. LEDT induced an increase in both SOD and CAT activity, with effects observable in the acute but not in the chronic. And finally, pre-administration of naloxone or fucoidin prevented LEDT analgesic effect.<br />Conclusions: These data contribute to the understanding of the neurobiological mechanisms involved in the therapeutic effect of LEDT as well as provides additional support for its use in the treatment of painful conditions of inflammatory etiology.<br /> (Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Catalase metabolism
Disease Models, Animal
Freund's Adjuvant
Hot Temperature
Hyperalgesia metabolism
Inflammation metabolism
Inflammation therapy
Interleukin-1beta metabolism
Male
Mice
Oxidative Stress physiology
Pain metabolism
Pain Management instrumentation
Phototherapy instrumentation
Superoxide Dismutase metabolism
Thiobarbituric Acid Reactive Substances metabolism
Touch
Treatment Outcome
Tumor Necrosis Factor-alpha metabolism
Antioxidants metabolism
Hyperalgesia therapy
Interleukin-10 metabolism
Pain Management methods
Phototherapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7544
- Volume :
- 324
- Database :
- MEDLINE
- Journal :
- Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 27001179
- Full Text :
- https://doi.org/10.1016/j.neuroscience.2016.03.035