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Monokine induced by interferon gamma (MIG/CXCL9) is an independent prognostic factor in newly diagnosed myeloma.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2016 Nov; Vol. 57 (11), pp. 2516-25. Date of Electronic Publication: 2016 Mar 21. - Publication Year :
- 2016
-
Abstract
- Immune suppression is a hallmark of multiple myeloma (MM), but data on soluble factors involved in the fate of immune effector cells are limited. The CXCR3-binding chemokine monokine induced by interferon-gamma (MIG/CXCL9) has been associated with tumor progression, immune escape, and angiogenesis in several malignancies. We here aimed to evaluate the prognostic relevance of MIG in MM. MIG serum levels were significantly elevated in newly diagnosed MM patients (n = 105) compared to patients with monoclonal gammopathy of undetermined significance (MGUS; n = 17) and healthy controls (n = 37). MIG expression in stromal compartments but not purified MM cells correlated with serum levels. High MIG serum levels were significantly associated with established prognostic markers (international staging system: R = 0.25, p = 0.001; age: R = 0.47, p < 0.0001; lactate-dehydrogenase: R = 0.34, p = 0.0005) and poor overall survival (OS) (median OS 17.0 months vs. not reached, p < 0.001). A similar association was found for CXCL10 and CXCL11. Multivariate regression analysis indicated MIG as an independent prognostic factor of OS.
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Biomarkers
Chemokine CXCL9 blood
Chemokines metabolism
Combined Modality Therapy
Female
Gene Expression
Humans
Male
Middle Aged
Multiple Myeloma diagnosis
Multiple Myeloma therapy
Neoplasm Staging
Prognosis
Proportional Hazards Models
Protein Binding
Receptors, CXCR3 metabolism
Survival Analysis
Treatment Outcome
Chemokine CXCL9 metabolism
Multiple Myeloma metabolism
Multiple Myeloma mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 57
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 26999330
- Full Text :
- https://doi.org/10.3109/10428194.2016.1151511