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Waning immunity against mumps in vaccinated young adults, France 2013.
- Source :
-
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2016; Vol. 21 (10), pp. 30156. - Publication Year :
- 2016
-
Abstract
- In 2013, 15 clusters of mumps were notified in France; 72% (82/114) of the cases had been vaccinated twice with measles-mumps-rubella vaccine. To determine whether the risk of mumps increased with time since the last vaccination, we conducted a case-control study among clusters in universities and military barracks. A confirmed case had an inflammation of a salivary gland plus laboratory confirmation in 2013. A probable case presented with inflammation of a salivary gland in 2013 either lasting for > 2 days or with epidemiological link to a confirmed case. Controls had no mumps symptoms and attended the same university course, student party or military barracks. We collected clinical and vaccination data via web questionnaire and medical records. We calculated adjusted odds ratios (aOR) using logistic regression. 59% (50/85) of cases and 62% (199/321) of controls had been vaccinated twice. The odds of mumps increased for twice-vaccinated individuals by 10% for every year that had passed since the second dose (aOR 1.10; 95% confidence interval (CI): 1.02-1.19; p = 0.02). Mumps immunity waned with increasing time since vaccination. Our findings contributed to the French High Council of Public Health's decision to recommend a third MMR dose during outbreaks for individuals whose second dose dates > 10 years.
- Subjects :
- Adolescent
Case-Control Studies
Female
France
Humans
Male
Measles-Mumps-Rubella Vaccine administration & dosage
Measles-Mumps-Rubella Vaccine immunology
Mumps prevention & control
Mumps virus genetics
Mumps virus isolation & purification
Students statistics & numerical data
Surveys and Questionnaires
Vaccination statistics & numerical data
Young Adult
Disease Notification statistics & numerical data
Disease Outbreaks
Mumps epidemiology
Mumps immunology
Mumps Vaccine administration & dosage
Mumps Vaccine immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1560-7917
- Volume :
- 21
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 26987576
- Full Text :
- https://doi.org/10.2807/1560-7917.ES.2016.21.10.30156