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Does Donation After Cardiac Death Utilization Adversely Affect Hepatocellular Cancer Survival?
- Source :
-
Transplantation [Transplantation] 2016 Sep; Vol. 100 (9), pp. 1916-24. - Publication Year :
- 2016
-
Abstract
- Background: Hepatocellular cancer (HCC) is an established indication for liver transplantation. This group is often allocated a donor after cardiac death (DCD) liver as a solution for waiting times. There are concerns that this approach may oncologically disadvantage HCC recipients. The aim of this study was to determine whether DCD transplantation was associated with poorer cancer-related survival in HCC.<br />Methods: Study population was from a single institute (2001-2014) with an HCC listing diagnosis. Variables related to recipient, tumor, and graft were analyzed to determine association with HCC death.<br />Results: There were 347 recipients listed for HCC of which 91 received a DCD. Donor after cardiac death and donor after brain stem death (DBD) had equivalent 1-, 3-, and 5-year overall (P = 0.115) and cancer-specific survival (P = 0.7). On univariate analysis recipient age, sex, model for end stage liver disease, viral etiology had no bearing on the risk of HCC death. Neither did the graft variables of type (DCD vs DBD), donor age, steatosis, cold ischemic time, peak aspartate transaminase, day 5 bilirubin or international normalized ratio after transplant. Only tumor variables of alpha-fetoprotein, number, total diameter, microvascular invasion, and differentiation were predictors of HCC death. On multivariate analysis, predictors of HCC death remained tumor number (P = 0.002), total diameter of tumor(s) (P < 0.001), microvascular invasion (P = 0.025), and poor differentiation (P = 0.021).<br />Conclusions: Donor liver quality in terms of graft type (DCD) has no influence on cancer related survival in transplant for HCC (hazards ratio, 1.143; 95% confidence interval, 0.528-2.423; P = 0.752).
- Subjects :
- Aged
Carcinoma, Hepatocellular mortality
Carcinoma, Hepatocellular pathology
Cause of Death
Cell Differentiation
Chi-Square Distribution
Databases, Factual
Donor Selection
Female
Humans
Kaplan-Meier Estimate
Liver Neoplasms mortality
Liver Neoplasms pathology
Liver Transplantation adverse effects
Liver Transplantation mortality
London
Male
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
Proportional Hazards Models
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Tumor Burden
Waiting Lists
Carcinoma, Hepatocellular surgery
Heart Diseases mortality
Liver Neoplasms surgery
Liver Transplantation methods
Tissue Donors supply & distribution
Subjects
Details
- Language :
- English
- ISSN :
- 1534-6080
- Volume :
- 100
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 26982954
- Full Text :
- https://doi.org/10.1097/TP.0000000000001150