Is there a preferred diuretic class for patients with renal impairment and hypertension?

Authors :: Izzo JL Jr
Tobe SW
Source :: Journal of the American Society of Hypertension : JASH [J Am Soc Hypertens] 2016 Apr; Vol. 10 (4), pp. 282-4. Date of Electronic Publication: 2016 Feb 23.
Publication Year :: 2016
Abstract: It is widely believed that "high-ceiling" loop diuretics are required in patients with renal impairment and that "low-ceiling" thiazides are not sufficiently potent to cause meaningful natriuresis and diuresis. If this statement is true, at what level of renal function do thiazides lose their punch? Another related issue is the enlightened use of diuretic combinations. Use of diuretics in chronic kidney disease and hypertension has been addressed in the many guidelines, but further insight is provided in this installment of the "Controversies" series by two well-known authorities, William Elliott, M.D. Ph.D. and Rajiv Agarwal, M.D.<br /> (Copyright © 2016 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.)

Subjects :: Drug Therapy, Combination
Humans
Hypertension complications
Practice Guidelines as Topic
Renal Insufficiency, Chronic complications
Sodium urine
Treatment Outcome
Antihypertensive Agents therapeutic use
Diuretics therapeutic use
Hypertension drug therapy
Renal Insufficiency, Chronic drug therapy
Sodium Potassium Chloride Symporter Inhibitors therapeutic use
Thiazides therapeutic use

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