Back to Search
Start Over
Safety and efficacy of tuberculin skin testing with microneedle MicronJet600™ in healthy adults.
- Source :
-
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2016 Apr; Vol. 20 (4), pp. 500-4. - Publication Year :
- 2016
-
Abstract
- Setting: Intradermal injection using a syringe and needle is generally accepted as the most accurate method for the tuberculin skin test (TST). However, the Mantoux technique using a conventional needle is often difficult to perform reliably, affecting testing results and safety.<br />Objective: We evaluated the efficacy and safety of a novel intradermal injection device, the MicronJet600(TM) microneedle, compared with conventional injection in terms of skin reactivity to the TST.<br />Design: A prospective, open-label clinical study was conducted. The TST was administered by both methods in the same subject. For pain assessment, participants filled in a visual analogue scale (VAS) after each TST. Any side effects due to TST or injections were observed.<br />Results: TST reaction rates (cut-off ⩾5 mm) from microneedles and needles were respectively 44.0% and 47.2%, with no significant difference between the two. Furthermore, agreement of positivity between the two methods was excellent with both 5 mm and 10 mm cut-off values. However, the level of pain experienced when microneedles were used for TST was significantly lower than with conventional needles. No adverse effects were attributed to the MicronJet device.<br />Conclusion: The novel microneedle device used for TST in this study was effective, safe and less painful in healthy adult volunteers.
- Subjects :
- Adult
Asian People
Body Mass Index
Dose-Response Relationship, Drug
Female
Humans
Injections, Intradermal adverse effects
Injections, Intradermal instrumentation
Male
Middle Aged
Pain diagnosis
Pain etiology
Prospective Studies
Republic of Korea
Syringes
Tuberculin administration & dosage
Tuberculin immunology
Tuberculin Test adverse effects
Young Adult
Needles
Tuberculin Test instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1815-7920
- Volume :
- 20
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
- Publication Type :
- Academic Journal
- Accession number :
- 26970160
- Full Text :
- https://doi.org/10.5588/ijtld.15.0678