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Cortisol response to acute stress in asthma: Moderation by depressive mood.

Authors :
Trueba AF
Simon E
Auchus RJ
Ritz T
Source :
Physiology & behavior [Physiol Behav] 2016 May 15; Vol. 159, pp. 20-6. Date of Electronic Publication: 2016 Mar 07.
Publication Year :
2016

Abstract

Both individuals with asthma and depression show signs of a dysregulated hypothalamus-pituitary-adrenal axis. However, little is known about the cortisol response to stress in the context of co-occurring asthma and depressive mood. Thirty-nine individuals with asthma and 41 healthy controls underwent a combined speech and mental arithmetic stressor. During the course of the laboratory session, salivary cortisol was collected 5 times, with 1 sample at 0min before the stressor and 4 samples at 0, 15, 30 and 45min after the stressor. Depressive mood in the past week was assessed with the Hospital Anxiety and Depression Scale at the beginning of the session. Depressive symptoms moderated cortisol response to the acute stressor, but only among asthmatic patients. Higher depressive mood was associated with a significant increase in cortisol, whereas low depressive mood was associated with no cortisol response. In healthy participants, depressive mood had no substantial effect on cortisol response to the stressor. These findings suggest that depressive mood and chronic inflammatory diseases such as asthma can interact to augment cortisol response to stress.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1873-507X
Volume :
159
Database :
MEDLINE
Journal :
Physiology & behavior
Publication Type :
Academic Journal
Accession number :
26965527
Full Text :
https://doi.org/10.1016/j.physbeh.2016.03.005