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Radiotherapy-induced tumors of the spine, peripheral nerve, and spinal cord: Case report and literature review.
- Source :
-
Surgical neurology international [Surg Neurol Int] 2016 Feb 10; Vol. 7 (Suppl 4), pp. S108-15. Date of Electronic Publication: 2016 Feb 10 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Background: The development of a secondary malignancy in the field of radiation is a rare but well-recognized hazard of cancer treatment. The radiotherapy-induced (RT-I) tumors are even more aggressive and potentially lethal than the primary tumor. To goal of this article is to report a case of RT-I neural tumor located in the peripheral nerve and spinal cord and to perform a literature review of the subject.<br />Case Reports: Thirty-year male with symptoms of hypoesthesia and dysesthesia of the L5 nerve root distribution and previous treatment of a testicular seminoma 20 years previously. The lumbar magnetic resonance imaging showed the growth of a nerve root tumor. Surgery was performed, and a fusiform tumor was resected with clear margins. The anatomopathological and immunohistochemical studies were compatible with a malignant peripheral nerve sheath tumor. A total of 30 cases were included in the review. The mean age of the patients at diagnosis of the induced tumor was 39.36 (±16.74) years. Most were male (63.3%). The main type of primary disease was neural tumors (30%). The most common type of histology was fibrosarcoma (20.0%). No difference was found in age, gender, and time of diagnosis between neural and nonneural tumors. The mean survival after the diagnosis of the secondary tumor was 10.7 months (±13.27), and neural tumors had a longer survival period (P = 0.031).<br />Conclusion: The current gold standard therapy is complete resection with clear margins, since most tumors do not respond to chemotherapy and RT. The neural type of RT-I tumor presented a longer survival period.
Details
- Language :
- English
- ISSN :
- 2229-5097
- Volume :
- 7
- Issue :
- Suppl 4
- Database :
- MEDLINE
- Journal :
- Surgical neurology international
- Publication Type :
- Report
- Accession number :
- 26958426
- Full Text :
- https://doi.org/10.4103/2152-7806.176131