Back to Search
Start Over
Inducible clindamycin resistance and nasal carriage rates of Staphylococcus aureus among healthcare workers and community members.
- Source :
-
African health sciences [Afr Health Sci] 2015 Sep; Vol. 15 (3), pp. 861-7. - Publication Year :
- 2015
-
Abstract
- Background: Nasal carriage of Staphylococcus aureus is becoming an increasing problem among healthcare workers and community individuals.<br />Objectives: To determine the prevalence of methicillin-resistant S. aureus (MRSA) nasal colonization and inducible clindamycin resistance (ICR) of S. aureus among healthcare workers at Soba University Hospital and community members in Khartoum State, Sudan.<br />Methods: Five hundred nasal swabs samples were collected during March 2009 to April 2010. Isolates were identified using conventional laboratory assays and MRSA determined by the disk diffusion method. The D-test was performed for detection of ICR isolates with Clinical Laboratory Standard Institute guidelines.<br />Results: Of the 114 S. aureus isolated, 20.2% represented MRSA. The occurrence of MRSA was significantly higher among healthcare worker than community individuals [32.7% (18/55) vs. 6.9% (5/59)] (p=0.001). Overall the 114 S. aureus isolates tested for ICR by D-test, 29 (25.4%) yielded inducible resistance. Significantly higher (p=0.026) ICR was detected among MRSA (43.5%) than methicillin-susceptible S. aureus (MSSA) (20.9%).<br />Conclusion: MRSA nasal carriage among healthcare workers needs infection control practice in hospitals to prevent transmission of MRSA. The occurrence of ICR in S. aureus is of a great concern, D- test should be carried out routinely in our hospitals to avoid therapeutic failure.
- Subjects :
- Humans
Methicillin Resistance
Microbial Sensitivity Tests
Nose microbiology
Prevalence
Staphylococcal Infections drug therapy
Staphylococcal Infections epidemiology
Staphylococcal Infections microbiology
Staphylococcus aureus isolation & purification
Sudan epidemiology
Anti-Bacterial Agents pharmacology
Carrier State epidemiology
Clindamycin pharmacology
Health Personnel statistics & numerical data
Infectious Disease Transmission, Professional-to-Patient prevention & control
Methicillin-Resistant Staphylococcus aureus drug effects
Methicillin-Resistant Staphylococcus aureus isolation & purification
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1729-0503
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- African health sciences
- Publication Type :
- Academic Journal
- Accession number :
- 26957975
- Full Text :
- https://doi.org/10.4314/ahs.v15i3.21