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High urinary sulfate concentration is associated with reduced risk of renal disease progression in type 2 diabetes.
- Source :
-
Nitric oxide : biology and chemistry [Nitric Oxide] 2016 May 01; Vol. 55-56, pp. 18-24. Date of Electronic Publication: 2016 Mar 04. - Publication Year :
- 2016
-
Abstract
- Diabetes is associated with a high incidence of microvascular disease, including nephropathy. Diabetic nephropathy is the most common cause of chronic kidney disease in the Western world. Sulfate in the urine is the metabolic end product of hydrogen sulfide (H2S), a recent discovered gaseous signaling molecule. Urinary sulfate has earlier shown beneficial predictive properties in renal transplant recipients. Based on the protective role of exogenous H2S in experimental models of diabetic nephropathy, we aimed to cross-sectionally investigate the association of sulfate with renal risk markers, and to prospectively investigate its predictive value for renal events in patients with diabetic nephropathy. Post-hoc analysis on data of the sulodexide macroalbuminuria (Sun-MACRO) trial and the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study was performed. A total of 1004 patients with type 2 diabetes were included. Urinary sulfate concentration was measured and cross-sectionally associated to renal risk markers by linear regression. Multivariable Cox regression analysis was performed to assess the prospective association of sulfate with renal events, which was defined as end stage renal disease or a doubling of baseline serum creatinine. Mean age was 63 ± 9 years, median sulfate concentration was 8.0 (IQR 5.8-11.4) mmol/L. Urinary sulfate positively associated with male gender, hemoglobin, and negatively associated with albuminuria at baseline. During follow-up for 12 (IQR 6-18) months, 38 renal events occurred. Each doubling of urinary sulfate was associated with a 19% (95%CI 1%-34%) lower risk of renal events, independent of adjustment for potential confounders, including age, estimated glomerular filtration rate (eGFR), and albuminuria. To conclude, higher urinary sulfate concentration is associated with a more beneficial profile of renal risk markers, and is independently associated with a reduced risk for renal events in type 2 diabetes patients with nephropathy.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Albuminuria etiology
Albuminuria physiopathology
Creatinine blood
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 physiopathology
Diabetic Nephropathies etiology
Diabetic Nephropathies physiopathology
Disease Progression
Female
Glomerular Filtration Rate
Hemoglobins analysis
Humans
Male
Middle Aged
Renal Insufficiency, Chronic etiology
Renal Insufficiency, Chronic physiopathology
Serum Albumin analysis
Albuminuria urine
Diabetes Mellitus, Type 2 urine
Diabetic Nephropathies urine
Renal Insufficiency, Chronic urine
Sulfates urine
Subjects
Details
- Language :
- English
- ISSN :
- 1089-8611
- Volume :
- 55-56
- Database :
- MEDLINE
- Journal :
- Nitric oxide : biology and chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26952289
- Full Text :
- https://doi.org/10.1016/j.niox.2016.03.001