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Different in vitro proliferation and cytokine-production inhibition of memory T-cell subsets after calcineurin and mammalian target of rapamycin inhibitors treatment.
- Source :
-
Immunology [Immunology] 2016 Jun; Vol. 148 (2), pp. 206-15. Date of Electronic Publication: 2016 Mar 29. - Publication Year :
- 2016
-
Abstract
- Calcineurin inhibitors (CNI) and mammalian target of rapamycin inhibitors (mTORi) are the main immunosuppressants used for long-term maintenance therapy in transplant recipients to avoid acute rejection episodes. Both groups of immunosuppressants have wide effects and are focused against the T cells, although different impacts on specific T-cell subsets, such as regulatory T cells, have been demonstrated. A greater knowledge of the impact of immunosuppression on the cellular components involved in allograft rejection could facilitate decisions for individualized immunosuppression when an acute rejection event is suspected. Memory T cells have recently gained focus because they might induce a more potent response compared with naive cells. The impact of immunosuppressants on different memory T-cell subsets remains unclear. In the present study, we have studied the specific impact of CNI (tacrolimus) and mTORi (rapamycin and everolimus) over memory and naive CD4(+) T cells. To do so, we have analysed the proliferation, phenotypic changes and cytokine synthesis in vitro in the presence of these immunosuppressants. The present work shows a more potent effect of CNI on proliferation and cytokine production in naive and memory T cells. However, the mTORi permit the differentiation of naive T cells to the memory phenotype and allow the production of interleukin-2. Taken together, our data show evidence to support the combined use of CNI and mTORi in transplant immunosuppression.<br /> (© 2016 John Wiley & Sons Ltd.)
- Subjects :
- CD4-Positive T-Lymphocytes immunology
Calcineurin Inhibitors pharmacology
Cell Proliferation drug effects
Cells, Cultured
Everolimus pharmacology
Humans
Immunologic Memory drug effects
Lymphocyte Activation drug effects
Sirolimus pharmacology
T-Lymphocyte Subsets immunology
TOR Serine-Threonine Kinases antagonists & inhibitors
Tacrolimus pharmacology
CD4-Positive T-Lymphocytes drug effects
Graft Rejection prevention & control
Immunosuppressive Agents pharmacology
Organ Transplantation
T-Lymphocyte Subsets drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2567
- Volume :
- 148
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26931075
- Full Text :
- https://doi.org/10.1111/imm.12603