Granzyme M and K release in human experimental endotoxemia.

Authors :: Wensink AC
Wiewel MA
Jongeneel LH
Boes M
van der Poll T
Hack CE
Bovenschen N
Source :: Immunobiology [Immunobiology] 2016 Jul; Vol. 221 (7), pp. 773-7. Date of Electronic Publication: 2016 Feb 24.
Publication Year :: 2016
Abstract: Granzymes are serine proteases involved in killing of tumor cells and virally infected cells. However, granzymes are also upregulated in blood under inflammatory conditions and contribute to cytokine release and processing. Here, we show that granzyme M (GrM) and to a lesser extent GrK are transiently elevated in the circulation following LPS administration in humans. GrM is released upon stimulation of whole blood with LPS or the gram-negative bacteria Escherichia coli BL21, Pseudomonas aeruginosa, and Neisseria meningitidis. GrK is only released upon stimulation with P. aeruginosa. Thus, GrM and GrK are differentially released in response to LPS and gram-negative bacteria.<br /> (Copyright © 2016 Elsevier GmbH. All rights reserved.)