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Ex Vivo Artifacts and Histopathologic Pitfalls in the Lung.
- Source :
-
Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2016 Mar; Vol. 140 (3), pp. 212-20. - Publication Year :
- 2016
-
Abstract
- Context: Surgical and pathologic handling of lung physically affects lung tissue. This leads to artifacts that alter the morphologic appearance of pulmonary parenchyma.<br />Objective: To describe and illustrate mechanisms of ex vivo artifacts that may lead to diagnostic pitfalls.<br />Design: In this study 4 mechanisms of ex vivo artifacts and corresponding diagnostic pitfalls are described and illustrated.<br />Results: The 4 patterns of artifacts are: (1) surgical collapse, due to the removal of air and blood from pulmonary resections; (2) ex vivo contraction of bronchial and bronchiolar smooth muscle; (3) clamping edema of open lung biopsies; and (4) spreading of tissue fragments and individual cells through a knife surface. Morphologic pitfalls include diagnostic patterns of adenocarcinoma, asthma, constrictive bronchiolitis, and lymphedema.<br />Conclusion: Four patterns of pulmonary ex vivo artifacts are important to recognize in order to avoid morphologic misinterpretations.
- Subjects :
- Adenocarcinoma diagnosis
Adenocarcinoma metabolism
Adenocarcinoma pathology
Adenocarcinoma surgery
Artifacts
Asthma diagnosis
Asthma metabolism
Asthma pathology
Asthma surgery
Biomarkers metabolism
Biopsy adverse effects
Bronchioles metabolism
Bronchioles pathology
Bronchioles surgery
Bronchiolitis Obliterans diagnosis
Bronchiolitis Obliterans metabolism
Bronchiolitis Obliterans pathology
Bronchiolitis Obliterans surgery
Diagnosis, Differential
Diagnostic Errors classification
Humans
Lung blood supply
Lung metabolism
Lung surgery
Lung Diseases diagnosis
Lung Diseases metabolism
Lung Diseases surgery
Lung Neoplasms diagnosis
Lung Neoplasms metabolism
Lung Neoplasms pathology
Lung Neoplasms surgery
Lymphedema diagnosis
Lymphedema metabolism
Lymphedema pathology
Lymphedema surgery
Muscle Contraction
Muscle, Smooth metabolism
Muscle, Smooth pathology
Muscle, Smooth surgery
Neoplasm Seeding
Respiratory Mucosa blood supply
Respiratory Mucosa metabolism
Respiratory Mucosa surgery
Specimen Handling adverse effects
Diagnostic Errors prevention & control
Lung pathology
Lung Diseases pathology
Respiratory Mucosa pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1543-2165
- Volume :
- 140
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of pathology & laboratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26927715
- Full Text :
- https://doi.org/10.5858/arpa.2015-0292-OA