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Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei).
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2016 Mar; Vol. 39, pp. 195-201. Date of Electronic Publication: 2015 Dec 31. - Publication Year :
- 2016
-
Abstract
- Amyloid beta (Aβ) and tau pathology have been described in the brains of captive aged great apes, but the natural progression of these age-related pathologies from wild great apes, including the gorilla, is unknown. In our previous study of Western lowland gorillas (Gorilla gorilla gorilla) who were housed in American Zoos and Aquariums-accredited facilities, we found an age-related increase in Aβ-positive plaques and vasculature, tau-positive astrocytes, oligodendrocyte coiled bodies, and neuritic clusters in the neocortex as well as hippocampus in older animals. Here, we demonstrate that aged wild mountain gorillas (Gorilla beringei beringei), who spent their entire lives in their natural habitat, also display an age-related increase in amyloid precursor protein (APP) and/or Aβ-immunoreactive blood vessels and plaques, but very limited tau pathology, in the frontal cortex. These results indicate that Aβ and tau lesions are age-related events that occur in the brain of gorillas living in captivity and in the wild.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Amyloid beta-Protein Precursor metabolism
Animals
Animals, Wild
Animals, Zoo
Astrocytes metabolism
Astrocytes pathology
Female
Frontal Lobe cytology
Gorilla gorilla
Hippocampus cytology
Hippocampus metabolism
Hippocampus pathology
Male
Neocortex cytology
Neocortex metabolism
Neocortex pathology
Oligodendroglia metabolism
Oligodendroglia pathology
Plaque, Amyloid metabolism
Plaque, Amyloid pathology
Aging metabolism
Aging pathology
Alzheimer Disease metabolism
Alzheimer Disease pathology
Amyloid beta-Peptides metabolism
Frontal Lobe metabolism
Frontal Lobe pathology
tau Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 39
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 26923416
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2015.12.017