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Genomic Bayesian Prediction Model for Count Data with Genotype × Environment Interaction.

Authors :
Montesinos-López A
Montesinos-López OA
Crossa J
Burgueño J
Eskridge KM
Falconi-Castillo E
He X
Singh P
Cichy K
Source :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2016 May 03; Vol. 6 (5), pp. 1165-77. Date of Electronic Publication: 2016 May 03.
Publication Year :
2016

Abstract

Genomic tools allow the study of the whole genome, and facilitate the study of genotype-environment combinations and their relationship with phenotype. However, most genomic prediction models developed so far are appropriate for Gaussian phenotypes. For this reason, appropriate genomic prediction models are needed for count data, since the conventional regression models used on count data with a large sample size ([Formula: see text]) and a small number of parameters (p) cannot be used for genomic-enabled prediction where the number of parameters (p) is larger than the sample size ([Formula: see text]). Here, we propose a Bayesian mixed-negative binomial (BMNB) genomic regression model for counts that takes into account genotype by environment [Formula: see text] interaction. We also provide all the full conditional distributions to implement a Gibbs sampler. We evaluated the proposed model using a simulated data set, and a real wheat data set from the International Maize and Wheat Improvement Center (CIMMYT) and collaborators. Results indicate that our BMNB model provides a viable option for analyzing count data.<br /> (Copyright © 2016 Montesinos-López et al.)

Details

Language :
English
ISSN :
2160-1836
Volume :
6
Issue :
5
Database :
MEDLINE
Journal :
G3 (Bethesda, Md.)
Publication Type :
Academic Journal
Accession number :
26921298
Full Text :
https://doi.org/10.1534/g3.116.028118