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Pharmacoresistant temporal lobe epilepsy modifies histamine turnover and H3 receptor function in the human hippocampus and temporal neocortex.
- Source :
-
Epilepsia [Epilepsia] 2016 Apr; Vol. 57 (4), pp. e76-80. Date of Electronic Publication: 2016 Feb 24. - Publication Year :
- 2016
-
Abstract
- Experiments were designed to evaluate the tissue content of tele-methylhistamine (t-MeHA) and histamine as well as H3 receptor (H3 Rs) binding and activation of the heterotrimeric guanine nucleotide binding αi/o proteins (Gαi/o) coupled to these receptors in the hippocampus and temporal neocortex of patients (n = 10) with pharmacoresistant mesial temporal lobe epilepsy (MTLE). Patients with MTLE showed elevated tissue content of t-MeHA in the hippocampus. Analyses revealed that a younger age at seizure onset was correlated with a higher tissue content of t-MeHA, lower H3 R binding, and lower efficacy of Gαi/o protein activation in the hippocampus. We conclude that the hippocampus shows a reduction in the H3 R function associated with enhanced histamine. In contrast, the temporal neocortex displayed a high efficacy of H3 Rs Gαi/o protein activation that was associated with low tissue contents of histamine and t-MeHA. These results indicate an overactivation of H3 Rs leading to decreased histamine in the temporal neocortex. However, this situation was lessened in circumstances such as a longer duration of epilepsy or higher seizure frequency. It is concluded that decrease in H3 Rs function and enhanced levels of histamine may contribute to the epileptic activity in the hippocampus and temporal neocortex of patients with pharmacoresistant MTLE.<br /> (Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.)
- Subjects :
- Adult
Drug Resistant Epilepsy pathology
Epilepsy, Temporal Lobe pathology
Female
Hippocampus pathology
Humans
Male
Neocortex metabolism
Temporal Lobe pathology
Young Adult
Drug Resistant Epilepsy metabolism
Epilepsy, Temporal Lobe metabolism
Hippocampus metabolism
Histamine metabolism
Receptors, Histamine H3 metabolism
Temporal Lobe metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1528-1167
- Volume :
- 57
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Epilepsia
- Publication Type :
- Academic Journal
- Accession number :
- 26915454
- Full Text :
- https://doi.org/10.1111/epi.13329