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Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 2016 May; Vol. 233 (10), pp. 1829-35. Date of Electronic Publication: 2016 Feb 25. - Publication Year :
- 2016
-
Abstract
- Rationale: Although nicotine exposure upregulates the α4β2* subtype of nicotinic acetylcholine receptors (nAChRs), the upregulation of nAChRs in non-human primates voluntarily self-administering nicotine has never been demonstrated.<br />Objectives: The objective of the study is to determine if short access to nicotine in a non-human primate model of nicotine self-administration is sufficient to induce nAChRs upregulation.<br />Methods: We combined a nicotine self-administration paradigm with in vivo measure of α4β2* nAChRs using 2-[(18)F]fluoro-A-85380 (2-FA) and positron emission tomography (PET) in six squirrel monkeys. PET measurement was performed before and after intravenous nicotine self-administration (unit dose 10 μg/kg per injection). Monkeys were trained to self-administer nicotine under a fixed-ratio (FR) schedule of reinforcement. Intermittent access (1 h daily per weekday) to nicotine was allowed for 4 weeks and levels of α4β2* nAChRs were measured 4 days later.<br />Results: This intermittent access was sufficient to induce upregulation of α4β2* receptors in the whole brain (31 % upregulation) and in specific brain areas (+36 % in amygdala and +62 % in putamen).<br />Conclusions: These results indicate that intermittent nicotine exposure is sufficient to produce change in nAChRs expression.
- Subjects :
- Animals
Azetidines analysis
Brain diagnostic imaging
Brain metabolism
Fluorine Radioisotopes analysis
Male
Positron-Emission Tomography methods
Radiopharmaceuticals analysis
Receptors, Nicotinic analysis
Self Administration
Brain drug effects
Nicotine administration & dosage
Receptors, Nicotinic biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2072
- Volume :
- 233
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 26911381
- Full Text :
- https://doi.org/10.1007/s00213-016-4250-9