Back to Search Start Over

Non-coding RNAs, the cutting edge of histone messages.

Authors :
Köhn M
Hüttelmaier S
Source :
RNA biology [RNA Biol] 2016; Vol. 13 (4), pp. 367-72. Date of Electronic Publication: 2016 Feb 24.
Publication Year :
2016

Abstract

In metazoan the 3'-end processing of histone mRNAs is a conserved process involving the concerted action of many protein factors and the non-coding U7 snRNA. Recently, we identified that the processing of histone pre-mRNAs is promoted by an additional ncRNA, the Y3-derived Y3** RNA. U7 modulates the association of the U7 snRNP whereas Y3** promotes recruitment of CPSF (cleavage and polyadenylation specific factor) proteins to nascent histone transcripts at histone locus bodies (HLBs) in mammals. This enhances the 3'-end cleavage of nascent histone pre-mRNAs and modulates HLB assembly. Here we discuss new insights in the role of ncRNAs in the spatiotemporal control of histone synthesis. We propose that ncRNAs scaffold the formation of functional protein-RNA complexes and their sequential deposition on nascent histone pre-mRNAs at HLBs. These findings add to the multiple roles of ncRNAs in controlling gene expression and may provide new avenues for targeting histone synthesis in cancer.

Details

Language :
English
ISSN :
1555-8584
Volume :
13
Issue :
4
Database :
MEDLINE
Journal :
RNA biology
Publication Type :
Academic Journal
Accession number :
26909464
Full Text :
https://doi.org/10.1080/15476286.2016.1152439