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Use of cinacalcet for the management of hyperparathyroidism in patients with different degrees of renal failure.

Authors :
Orellana JM
Esteban RJ
Castilla YA
Fernández-Castillo R
Nozal-Fernández G
Esteban MA
García-Valverde M
Bravo J
Source :
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia [Nefrologia] 2016; Vol. 36 (2), pp. 121-5. Date of Electronic Publication: 2016 Feb 20.
Publication Year :
2016

Abstract

Background: The effects of cinacalcet in persistent and/or hypercalcaemia-associated secondary hyperparathyroidism (SHPT) have been described in patients on dialysis.<br />Objectives: To evaluate the efficacy and safety of cinacalcet in SHPT not on dialysis and its effects on bone turnover markers.<br />Methods: Non-randomised, longitudinal, observational, analytical study of patients with chronic kidney disease (CKD) and SHPT (PTH> 80 pg/mL) as well as normo- or hypercalcaemia (≥8.5mg/dL), treated with cinacalcet.<br />Results: Mean cinacalcet dose was 30mg/day in 66.7%. We studied 15 patients (10 women), aged 66.0±17.93years. The aetiology was unknown in 20% of cases. Sociodemographic variables and renal function parameters were recorded. We compared values at baseline as well as after 6 and 12 months. Calcium (10.3±0.55 vs. 9.4±1.04) and iPTH (392.4±317.65 vs. 141.8±59.26) levels decreased. Increased levels of phosphorus (3.7±1.06 vs. 3.9±0.85) and ß-CTX (884.2±797.22 vs. 1053.6±999.00) were detected, although there were no significant changes in GFR, urinary calcium or other bone markers. Two patients withdrew from the study (gastrointestinal intolerance and parathyroidectomy, respectively).<br />Conclusions: Cinacalcet at low doses is effective in the management of SHPT in CKD patients who are not on dialysis. Its use reduces iPTH and calcaemia, without causing serious side effects or significant changes in renal function.<br /> (Copyright © 2015 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.)

Details

Language :
English; Spanish; Castilian
ISSN :
1989-2284
Volume :
36
Issue :
2
Database :
MEDLINE
Journal :
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
Publication Type :
Academic Journal
Accession number :
26906451
Full Text :
https://doi.org/10.1016/j.nefro.2015.10.017