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Vaccination of Elk (Cervus canadensis) with Brucella abortus Strain RB51 Overexpressing Superoxide Dismutase and Glycosyltransferase Genes Does Not Induce Adequate Protection against Experimental Brucella abortus Challenge.
- Source :
-
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2016 Feb 10; Vol. 6, pp. 10. Date of Electronic Publication: 2016 Feb 10 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- In recent years, elk (Cervus canadensis) have been implicated as the source of Brucella abortus infection for numerous cattle herds in the Greater Yellowstone Area. In the face of environmental and ecological changes on the landscape, the range of infected elk is expanding. Consequently, the development of effective disease management strategies for wild elk herds is of utmost importance, not only for the prevention of reintroduction of brucellosis to cattle, but also for the overall health of the Greater Yellowstone Area elk populations. In two studies, we evaluated the efficacy of B. abortus strain RB51 over-expressing superoxide dismutase and glycosyltransferase for protecting elk from infection and disease caused by B. abortus after experimental infection with a virulent B. abortus strain. Our data indicate that the recombinant vaccine does not protect elk against brucellosis. Further, work is needed for development of an effective brucellosis vaccine for use in elk.
- Subjects :
- Animals
Animals, Wild immunology
Antibodies, Bacterial
Antigens, Bacterial immunology
Brucellosis immunology
Brucellosis microbiology
Deer microbiology
Female
Glycosyltransferases genetics
Superoxide Dismutase genetics
Brucella Vaccine immunology
Brucella abortus immunology
Brucellosis prevention & control
Deer immunology
Glycosyltransferases biosynthesis
Superoxide Dismutase biosynthesis
Vaccination veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 2235-2988
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Frontiers in cellular and infection microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 26904509
- Full Text :
- https://doi.org/10.3389/fcimb.2016.00010