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Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival.
- Source :
-
Blood [Blood] 2016 Apr 07; Vol. 127 (14), pp. 1828-35. Date of Electronic Publication: 2016 Feb 22. - Publication Year :
- 2016
-
Abstract
- We studied the impact of a set of immune cells contained within granulocyte colony-stimulating factor-mobilized peripheral blood stem cell grafts (naïve and memory T-cell subsets, B cells, regulatory T cells, invariant natural killer T cells [iNKTs], NK cells, and dendritic cell subsets) in patients (n = 80) undergoing allogeneic stem cell transplantation (SCT), using the composite end point of graft-versus-host disease (GVHD)-free and progression-free survival (GPFS) as the primary end point. We observed that GPFS incidences in patients receiving iNKT doses above and below the median were 49% vs 22%, respectively (P= .007). In multivariate analysis, the iNKT dose was the only parameter with a significant impact on GPFS (hazard ratio = 0.48; 95% confidence interval, 0.27-0.85;P= .01). The incidences of severe grade III to IV acute GVHD and National Institutes of Health grade 2 to 3 chronic GVHD (12% and 16%, respectively) were low and associated with the use of antithymocyte globulin in 91% of patients. No difference in GVHD incidence was reported according to the iNKT dose. In conclusion, a higher dose of iNKTs within the graft is associated with an improved GPFS. These data may pave the way for prospective and active interventions aiming to manipulate the graft content to improve allo-SCT outcome.<br /> (© 2016 by The American Society of Hematology.)
- Subjects :
- Adolescent
Adult
Aged
Allografts
Child
Chronic Disease
Disease-Free Survival
Female
Humans
Male
Middle Aged
Retrospective Studies
Survival Rate
Antilymphocyte Serum administration & dosage
Graft vs Host Disease immunology
Graft vs Host Disease mortality
Graft vs Host Disease pathology
Graft vs Host Disease prevention & control
Natural Killer T-Cells immunology
Natural Killer T-Cells pathology
Stem Cell Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 127
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 26903546
- Full Text :
- https://doi.org/10.1182/blood-2015-12-688739