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Sericin/Dextran Injectable Hydrogel as an Optically Trackable Drug Delivery System for Malignant Melanoma Treatment.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2016 Mar; Vol. 8 (10), pp. 6411-22. Date of Electronic Publication: 2016 Mar 03. - Publication Year :
- 2016
-
Abstract
- Severe side effects of cancer chemotherapy prompt developing better drug delivery systems. Injectable hydrogels are an effective site-target system. For most of injectable hydrogels, once delivered in vivo, some properties including drug release and degradation, which are critical to chemotherapeutic effects and safety, are challenging to monitor. Developing a drug delivery system for effective cancer therapy with in vivo real-time noninvasive trackability is highly desired. Although fluorescence dyes are used for imaging hydrogels, the cytotoxicity limits their applications. By using sericin, a natural photoluminescent protein from silk, we successfully synthesized a hydrazone cross-linked sericin/dextran injectable hydrogel. This hydrogel is biodegradable and biocompatible. It achieves efficient drug loading and controlled release of both macromolecular and small molecular drugs. Notably, sericin's photoluminescence from this hydrogel is directly and stably correlated with its degradation, enabling long-term in vivo imaging and real-time monitoring of the remaining drug. The hydrogel loaded with Doxorubicin significantly suppresses tumor growth. Together, the work demonstrates the efficacy of this drug delivery system, and the in vivo effectiveness of this sericin-based optical monitoring strategy, providing a potential approach for improving hydrogel design toward optimal efficiency and safety of chemotherapies, which may be widely applicable to other drug delivery systems.
- Subjects :
- Animals
Cell Line, Tumor
Humans
Melanoma metabolism
Melanoma pathology
Mice
Xenograft Model Antitumor Assays
Dextrans chemistry
Dextrans pharmacology
Doxorubicin chemistry
Doxorubicin pharmacology
Drug Delivery Systems methods
Hydrogels chemistry
Hydrogels pharmacology
Melanoma drug therapy
Sericins chemistry
Sericins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 8
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 26900631
- Full Text :
- https://doi.org/10.1021/acsami.6b00959