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Nano-thick calcium oxide armed titanium: boosts bone cells against methicillin-resistant Staphylococcus aureus.
- Source :
-
Scientific reports [Sci Rep] 2016 Feb 22; Vol. 6, pp. 21761. Date of Electronic Publication: 2016 Feb 22. - Publication Year :
- 2016
-
Abstract
- Since the use of systemic antibiotics for preventing acute biomaterial-associated infections (BAIs) may build up bacterial resistance and result in huge medical costs and unpredictable mortality, new precaution strategies are required. Here, it demonstrated that titanium armed with a nano-thick calcium oxide layer was effective on averting methicillin-resistant Staphylococcus aureus (MRSA) infections in rabbits. The calcium oxide layer was constructed by, firstly, injecting of metallic calcium into titanium via a plasma immersion ion implantation process, and then transforming the outer most surface into oxide by exposing to the atmosphere. Although the calcium oxide armed titanium had a relative low reduction rate (~74%) in growth of MRSA in vitro, it could markedly promote the osteogenic differentiation of bone marrow stem cells (BMSCs), restore local bone integration against the challenge of MRSA, and decrease the incidence of MRSA infection with a rate of 100% (compared to the titanium control). This study demonstrated for the first time that calcium, as one of the major elements in a human body, could be engineered to avert MRSA infections, which is promising as a safe precaution of disinfection for implantable biomedical devices.
- Subjects :
- Alkaline Phosphatase genetics
Alkaline Phosphatase metabolism
Animals
Anti-Bacterial Agents chemical synthesis
Biomarkers metabolism
Bone Morphogenetic Proteins genetics
Bone Morphogenetic Proteins metabolism
Bone-Implant Interface
Calcium Compounds chemistry
Coated Materials, Biocompatible
Female
Gene Expression
Mesenchymal Stem Cells cytology
Mesenchymal Stem Cells drug effects
Mesenchymal Stem Cells metabolism
Methicillin-Resistant Staphylococcus aureus drug effects
Methicillin-Resistant Staphylococcus aureus growth & development
Nanostructures chemistry
Osteocalcin genetics
Osteocalcin metabolism
Osteogenesis genetics
Osteopontin genetics
Osteopontin metabolism
Oxides chemistry
Plasma Gases
Primary Cell Culture
Prostheses and Implants
Prosthesis-Related Infections microbiology
Rabbits
Staphylococcal Infections microbiology
Tibia drug effects
Tibia injuries
Tibia microbiology
Anti-Bacterial Agents pharmacology
Calcium Compounds pharmacology
Osteogenesis drug effects
Oxides pharmacology
Prosthesis-Related Infections prevention & control
Staphylococcal Infections prevention & control
Titanium chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 26899567
- Full Text :
- https://doi.org/10.1038/srep21761