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Transforming growth factor-beta blocks proliferation but not early mitogenic signaling events in T-lymphocytes.
- Source :
-
Experimental cell research [Exp Cell Res] 1989 Dec; Vol. 185 (2), pp. 529-34. - Publication Year :
- 1989
-
Abstract
- Transforming growth factor-beta (TGF-beta) inhibits the proliferation of T-lymphocytes in response to activation with mitogenic lectin. The influence of TGF-beta on elevation of cytosolic Ca2+, induction of proliferation-associated mRNA species, and total cellular RNA content has been studied. The cells seem to exit G0 when activated in the presence of TGF-beta, but they arrest in mid-G1 phase.
- Subjects :
- Acridine Orange
Animals
Calcium metabolism
Cattle
Cell Cycle drug effects
Cell Division drug effects
Flow Cytometry methods
Fluorescent Dyes
Genes drug effects
Histones genetics
Indoles
Ornithine Decarboxylase genetics
Protein-Tyrosine Kinases genetics
Proto-Oncogene Proteins genetics
Proto-Oncogene Proteins c-myc
Proto-Oncogenes drug effects
RNA, Messenger analysis
Signal Transduction drug effects
T-Lymphocytes cytology
T-Lymphocytes drug effects
Lymphocyte Activation drug effects
T-Lymphocytes immunology
Transforming Growth Factors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-4827
- Volume :
- 185
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Experimental cell research
- Publication Type :
- Academic Journal
- Accession number :
- 2689199
- Full Text :
- https://doi.org/10.1016/0014-4827(89)90321-2