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Structure, toxicity and antibiotic activity of gramicidin S and derivatives.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2016 May; Vol. 35 (5), pp. 763-9. Date of Electronic Publication: 2016 Feb 17. - Publication Year :
- 2016
-
Abstract
- Development of new antibiotics is declining whereas antibiotic resistance is rising, heralding a post-antibiotic era. Antimicrobial peptides such as gramicidin S (GS), exclusively topically used due to its hemolytic side-effect, could still be interesting as therapeutic compounds. By modifying the amino-acid composition of GS, we synthesized GS analogues. We now show that derivative VK7 has a lower MIC (7.8-31.2 μg/ml, median 15.6 μg/ml) against strains of multi-drug resistant (MDR) Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa than GS has (3.9-62.5 μg/ml, median 31.3 μg/ml). Low MICs for both VK7 and GS were observed for Staphylococcus aureus and Enterococcus faecium. VK7 showed reduced haemolysis and less lactate dehydrogenase release. All compounds were fully bactericidal at MIC values. Modification of GS enables production of novel derivatives potentially useful for systemic treatment of human infections.
- Subjects :
- Anti-Bacterial Agents toxicity
Cell Line, Tumor
Erythrocytes drug effects
Erythrocytes metabolism
Gramicidin toxicity
Hemolysis
Humans
Lactate Dehydrogenases biosynthesis
Microbial Sensitivity Tests
Molecular Structure
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Gramicidin chemistry
Gramicidin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 35
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 26886453
- Full Text :
- https://doi.org/10.1007/s10096-016-2595-y