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DIPNECH: Association Between Histopathology and Clinical Presentation.
- Source :
-
Lung [Lung] 2016 Apr; Vol. 194 (2), pp. 243-7. Date of Electronic Publication: 2016 Feb 15. - Publication Year :
- 2016
-
Abstract
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare disorder which can be an incidental finding in imaging tests performed during the investigation of another condition, or is the final diagnosis in patients evaluated for chronic obstructive complaints. To explore the possible association between specific histopathology features and the mode of clinical presentation, we retrieved the clinical, functional, radiological, and pathological data of all 13 patients diagnosed with DIPNECH at our Institution over a 14-year period (2000-2014). As compared to patients with incidental disease (6/13, 46 %), patients with symptomatic disease were younger [mean (SD): 57.7 vs. 68.7 years, p = 0.046], were more likely to have mosaic attenuation (100 vs. 0 %, p = 0.001) and small multiple nodules (100 vs. 17 %, p = 0.005) at CT, and showed a significantly higher number of foci of linear neuroendocrine proliferation [median (IQR): 28 (13-37) vs. 6 (5-13), p = 0.018] and of tumorlets [median (IQR): 10 (8-20) vs. 1 (1-1), p = 0.002] at histology. Incidental disease was found in association with pulmonary adenocarcinoma in five out of six patients (83.3 %). The results of our study provide preliminary evidence that symptomatic patients with DIPNECH represent a specific subset characterized by younger age and a higher burden of foci of neuroendocrine proliferation.
- Subjects :
- Adenocarcinoma complications
Adenocarcinoma pathology
Adenocarcinoma of Lung
Age Factors
Aged
Asymptomatic Diseases
Biopsy
Female
Humans
Hyperplasia
Italy
Lung diagnostic imaging
Lung physiopathology
Lung Diseases complications
Lung Diseases diagnostic imaging
Lung Diseases physiopathology
Lung Neoplasms complications
Lung Neoplasms pathology
Male
Middle Aged
Prognosis
Respiratory Function Tests
Severity of Illness Index
Time Factors
Tomography, X-Ray Computed
Cell Proliferation
Lung pathology
Lung Diseases pathology
Neuroendocrine Cells pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1750
- Volume :
- 194
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Lung
- Publication Type :
- Academic Journal
- Accession number :
- 26880164
- Full Text :
- https://doi.org/10.1007/s00408-016-9854-7