Back to Search
Start Over
[Intraocular Lens as a Drug Delivery Device: State of the Art and Future Perspective].
- Source :
-
Klinische Monatsblatter fur Augenheilkunde [Klin Monbl Augenheilkd] 2016 Feb; Vol. 233 (2), pp. 172-8. Date of Electronic Publication: 2016 Feb 15. - Publication Year :
- 2016
-
Abstract
- Development of an intraocular lens (IOL) as a drug delivery device has been pursued for many years and is a promising concept in modern cataract surgery. Common postoperative conditions such as posterior capsule opacification (PCO), intraocular inflammation or the rare but severe complications of cataract surgery like endophthalmitis are potential therapeutic targets for a drug-eluting IOL. There are three techniques of pharmacological IOL modification: Firstly, surface modification of the IOL ("coating"); secondly, IOL optic modification ("soaking") and lastly, loading the IOL haptics with a slow release system. The last option does not interfere with the IOL optics at all. Therefore, a broad spectrum of pharmacological agents needs to be assessed in preclinical and clinical studies to determine which agent/IOL combination is safe and efficient. For pharmacological PCO prophylaxis, erufosine-loaded IOLs are of great clinical interest. Heparin-coated IOLs might become clinically relevant for attenuation of intraocular inflammation after cataract surgery and cefuroxime-loaded IOLs for endophthalmitis prophylaxis.<br /> (Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Administration, Ophthalmic
Drug Implants chemical synthesis
Equipment Failure Analysis
Forecasting
Germany
Humans
Prosthesis Design trends
Anti-Inflammatory Agents administration & dosage
Cataract Extraction adverse effects
Drug Implants administration & dosage
Eye Diseases drug therapy
Eye Diseases etiology
Lenses, Intraocular trends
Subjects
Details
- Language :
- German
- ISSN :
- 1439-3999
- Volume :
- 233
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Klinische Monatsblatter fur Augenheilkunde
- Publication Type :
- Academic Journal
- Accession number :
- 26878733
- Full Text :
- https://doi.org/10.1055/s-0041-109512