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Expression of ROR1 has prognostic significance in triple negative breast cancer.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2016 May; Vol. 468 (5), pp. 589-95. Date of Electronic Publication: 2016 Feb 13. - Publication Year :
- 2016
-
Abstract
- Overexpression of receptor tyrosine kinase-like orphan receptor (ROR1) in a variety of human malignancies is associated with aggressive behaviour. Therapeutic agents targeting ROR1 have shown promising results in vivo and in vitro studies. In breast cancer, high-level expression of ROR1 mRNA is associated with high-grade tumours and metastasis. We investigated the prevalence and prognostic significance of ROR1 expression in triple negative breast cancer (TNBC). ROR1 was immunohistochemically stained on full-face sections of 210 TNBC patient samples. Forty-seven TNBC cases (22.4 %) showed strong ROR1 expression, which was associated with shorter disease-free survival (DFS; P = 0.00015), distant metastasis-free survival (DMFS; P = 0.00013) and overall survival (OS; P = 0.026) in univariate analyses. Results were confirmed by multivariate analysis. Seventy TNBC cases (33.3 %) with medullary features showed longer OS (P = 0.00013). We divided the whole series into two subgroups based on the presence or absence of medullary features. Strong ROR1 expression retained a predictive value of shorter DFS and DMFS in both subgroups. Our study suggests that strong ROR1 expression might be an independent adverse prognostic factor in TNBC patients and may serve as a potential marker for patient selection in ROR1-targeted therapy. More large-scale studies are needed to clarify its potential usefulness.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Prognosis
Receptor, ErbB-2 genetics
Receptors, Estrogen metabolism
Receptors, Progesterone genetics
Biomarkers, Tumor metabolism
Disease-Free Survival
Receptor Tyrosine Kinase-like Orphan Receptors metabolism
Triple Negative Breast Neoplasms diagnosis
Triple Negative Breast Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2307
- Volume :
- 468
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 26874851
- Full Text :
- https://doi.org/10.1007/s00428-016-1911-3