Acute myeloid leukemia patients' clinical response to idasanutlin (RG7388) is associated with pre-treatment MDM2 protein expression in leukemic blasts.

Authors :: Reis B
Jukofsky L
Chen G
Martinelli G
Zhong H
So WV
Dickinson MJ
Drummond M
Assouline S
Hashemyan M
Theron M
Blotner S
Lee JH
Kasner M
Yoon SS
Rueger R
Seiter K
Middleton SA
Kelly KR
Vey N
Yee K
Nichols G
Chen LC
Pierceall WE
Source :: Haematologica [Haematologica] 2016 May; Vol. 101 (5), pp. e185-8. Date of Electronic Publication: 2016 Feb 11.
Publication Year :: 2016

Subjects :: Female
Humans
Male
Pyrrolidines adverse effects
para-Aminobenzoates adverse effects
Blast Crisis blood
Blast Crisis drug therapy
Blast Crisis mortality
Gene Expression Regulation, Leukemic drug effects
Leukemia, Myeloid, Acute blood
Leukemia, Myeloid, Acute drug therapy
Leukemia, Myeloid, Acute mortality
Proto-Oncogene Proteins c-mdm2 biosynthesis
Pyrrolidines administration & dosage
para-Aminobenzoates administration & dosage

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